Interactions : אינטראקציות

7     DRUG INTERACTIONS

7.1   Use with Other Vaccines
Do not mix VAQTA with any other vaccine in the same syringe or vial. Use separate injection sites and syringes for each vaccine. Please refer to package inserts of coadministered vaccines.
In clinical trials in children, VAQTA was concomitantly administered with one or more of the following US licensed vaccines: Measles, Mumps, and Rubella Virus Vaccine, Live; Varicella Vaccine, Live; Measles, Mumps, Rubella, and Varicella Vaccine, Live; Pneumococcal 7-valent Conjugate Vaccine. Safety and immunogenicity were similar for concomitantly administered vaccines compared to separately administered vaccines.

In clinical trials in adults, VAQTA was concomitantly administered with typhoid Vi polysaccharide and yellow fever vaccines [see Adverse Reactions (6.1) and Clinical Studies (14.2, 14.7)]. Safety and immunogenicity were similar for concomitantly administered vaccines compared to separately administered vaccines.

Data on concomitant use of VAQTA with other vaccines such as combination diphtheria toxoid, tetanus toxoid and acellular pertussis vaccine and poliovirus vaccine are insufficient to support coadministration with VAQTA [see Clinical Studies (14.7)].

7.2   Use with Immune Globulin
VAQTA may be administered concomitantly with Immune Globulin, human, using separate sites and syringes. The recommended vaccination regimen for VAQTA should be followed. Consult the manufacturer's product circular for the appropriate dosage of Immune Globulin. A booster dose of VAQTA should be administered at the appropriate time as outlined in the recommended regimen for VAQTA [see Clinical Studies (14.5)].

7.3   Immunosuppressive Therapy
If VAQTA is administered to a person receiving immunosuppressive therapy, an adequate immunologic response may not be obtained.