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סיאנה SAYANA (MEDROXYPROGESTERONE ACETATE)

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צורת מתן:

תת-עורי : S.C

צורת מינון:

תרחיף להזרקה : SUSPENSION FOR INJECTION

Pregnancy & Lactation : הריון/הנקה

4.6    Fertility, pregnancy and lactation

Fertility
SAYANA® is indicated for the prevention of pregnancy. Women may experience a delay in return to fertility (conception) following discontinuation of SAYANA® (see section 4.4).

Pregnancy
SAYANA® is contraindicated in women who are pregnant. Some reports suggest an association between intrauterine exposure to progestational drugs in the first trimester of pregnancy and genital abnormalities in male and female fetuses. If SAYANA® is used during pregnancy, or if the patient becomes pregnant while using this drug, the patient should be warned of the potential hazard to the fetus.

One study found that infants from unintentional pregnancies that occurred 1 to 2 months after injection of DMPA-IM (150 mg) were at an increased risk of low birth weight; this, in turn, has been associated with an increased risk of neonatal death. However, the overall risk of this is very low because pregnancies while on DMPA-IM (150 mg) are uncommon.

Children exposed to MPA in utero and followed to adolescence showed no evidence of any adverse effects on their health including their physical, intellectual, sexual or social development.

Lactation
Low detectable amounts of drug have been identified in the milk of mothers receiving MPA. In nursing mothers treated with DMPA-IM (150 mg), milk composition, quality, and amount are not adversely affected. Neonates and infants exposed to MPA from breast milk have been studied for developmental and behavioural effects through puberty. No adverse effects have been noted.
However, due to limitations of the data regarding the effects of MPA in breastfed infants less than six weeks old, SAYANA® should be given no sooner than six weeks post partum when the infant's enzyme system is more developed.

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רישום

143 81 32952 00

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