Posology : מינונים

4.2   Posology and method of administration
Fixed combination Vasodip Combo should not be used for initial treatment of hypertension.

The combination Vasodip Combo 10 can be given to patients whose blood pressure cannot be controlled adequately by treatment with 10 mg lercanidipine alone.

The combination of Vasodip Combo 20 can be given to patients whose blood pressure cannot be controlled adequately by treatment with 20 mg enalapril alone.
Individual dose titration with the components can be recommended. When clinically appropriate, direct change from monotherapy to the fixed combination may be considered.

Posology
The recommended dose is 1 tablet taken once daily at least 15 minutes before a meal.

Elderly patients: The dose should depend on the patient's renal function (see "Use in renal impairment").

Children and adolescents under 18 years of age: Since there is no clinical experience in patients under 18 years of age, use in children and adolescents is not currently recommended.

Patients with renal impairment: Vasodip Combo is contraindicated in patients with severe renal dysfunction (creatinine clearance < 30 ml/min) or in patients undergoing haemodialysis (see sections 4.3 and 4.4). Particular caution is needed when initiating treatment in patients with mild to moderate renal dysfunction.

Patients with hepatic impairment: Vasodip Combo is contraindicated in severe hepatic dysfunction. Particular caution is needed when initiating treatment in patients with mild to moderate hepatic dysfunction.

Method of administration
Precautions to be taken before handling or administering the medicinal product:  Treatment should be preferably administered in the morning at least 15 minutes before a meal.
 This product should not be administered with grapefruit juice (see sections 4.3 and       4.5).