Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1    Pharmacodynamic properties
ATC Code: V03A F03 Detoxifying agents for antineoplastic treatment Calcium Folinate is used in conjunction with methotrexate, after methotrexate therapy is stopped to reduce the toxicity of the methotrexate, it is also administered in some megaloblastic anaemia.

Methotrexate rescue: Calcium Folinate acts partly by providing a fresh supply of tetrahydrofolate and also by competitively displacing methotrexate from dihydrofolate reductase so that its excretion is accelerated (methotrexate binds to the enzyme dihydrofolate reductase, which is responsible for reducing dietary folic acid Leucovorin Teva Tablets 15mg SPC Notification 06/2022 N.A
to dihydrofolate and tetrahydrofolate thus inhibiting its action).

Megaloblastic anaemia: Calcium Folinate is an active folic acid derivative and it can therefore relieve pathological conditions associated with folic acid deficiency e.g.
megaloblastic anaemia.

Pharmacokinetic Properties

5.2     Pharmacokinetic properties
Calcium Folinate is readily soluble; folinic acid is absorbed by the proximal portion of the small intestine. It is rapidly distributed in tissues.