Posology : מינונים

4.2 Posology and method of administration
For oral administration.

Calcium Folinate Rescue:
Adults and Children: In general up to 120mg in divided doses over 12 - 24 hours by intramuscular injection, bolus intravenous injection, or intravenous infusion in 0.9% w/v sodium chloride solution followed by 12 - 15mg intramuscularly or 15mg orally, every six hours for the next 48 hours.
Leucovorin Teva should not be given simultaneously with methotrexate as it may reduce or suppress its anti-neoplastic activity. It is recommended that administration should commence within the first 24 hours following methotrexate.
In overdose situations or when the half-life of methotrexate is increased (e.g.
renal function impairment or pleural or peritoneal effusions) it is important that Leucovorin Teva be given until the blood concentration of methotrexate declines to non-toxic concentrations. In these cases, doses of Leucovorin Teva equal to or greater than those of methotrexate should be given.

Leucovorin Teva Tablets 15mg SPC Notification 06/2022 N.A
Folinate deficiency:
Adults: 15mg (one tablet) per day.

Children up to 12 years: 0.25mg/kg/day.