Contraindications : התוויות נגד

4.3       Contraindications
•    SPORANOX Oral Solution is contraindicated in patients with a known hypersensitivity to itraconazole or to any of the excipients.
•    SPORANOX Oral Solution should not be administered to patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF except for the treatment of life-threatening or other serious infections. see 4.4 Special warnings and precautions for use.
•    SPORANOX Oral Solution must not be used during pregnancy for non-life-threatening indications (see section 4.6).

•    Co-administration of a number of CYP3A4 substrates is contraindicated with SPORANOX Oral Solution (see sections 4.4 and 4.5). These include:

Analgesics; Anaesthetics
Ergot alkaloids
(e.g. dihydroergotamine,
ergometrine, ergotamine,
methylergometrine)
Anti-bacterials for Systemic Use; Anti-mycobacterials; Antimycotics for Systemic Use Isavuconazole
Anthelmintics; Antiprotozoals
Halofantrine
Antihistamines for Systemic Use
Astemizole                        Mizolastine                               Terfenadine Antineoplastic Agents
Irinotecan
Antithrombotic Agents
Dabigatran                        Ticagrelor
Antivirals for Systemic Use
Ombitasvir/Paritaprevir/Ritonavir
(with or without Dasabuvir)
Cardiovascular System (Agents Acting on the Renin-Angiotensin System; Antihypertensives; Beta Blocking Agents; Calcium Channel Blockers; Cardiac Therapy; Diuretics) Aliskiren                         Dronedarone                               Nisoldipine Bepridil                          Eplerenone                                Quinidine Disopyramide                      Ivabradine                                Ranolazine Sildenafil (pulmonary
Dofetilide                        Lercanidipine hypertension)
Gastrointestinal Drugs, including Antidiarrheals, Intestinal Anti-inflammatory/Anti-infective Agents; Antiemetics and Antinauseants; Drugs for Constipation; Drugs for Functional Gastrointestinal Disorders
Cisapride                         Domperidone                               Naloxegol Lipid Modifying Agents
Lovastatin                        Lomitapide                                 Simvastatin Psychoanaleptics; Psycholeptics (e.g., antipsychotics, anxiolytics, and hypnotics) Lurasidone                        Pimozide                                  Sertindole Midazolam (oral)                  Quetiapine                                Triazolam Urologicals
Solifenacin (in patients with severe renal
Avanafil                          Darifenacin                               impairment or moderate to severe hepatic impairment)

Fesoterodine (in patients with moderate
Vardenafil (in patients
Dapoxetine                          or severe renal or hepatic impairment).   older than 75 years).
Miscellaneous Drugs and Other Substances
Eliglustat (in patients that are CYP2D6
Colchicine (in patients with renal poor metabolisers (PM), CYP2D6 or hepatic impairment)             intermediate metabolisers (IMs) or extensive metabolisers (EMs) that are


taking a strong or moderate CYP2D6 inhibitor).