Posology : מינונים

4.2    Posology and method of administration

1) Open the package and remove the test panel.

2) Remove the protective plastic from the test surface of the panel. Be careful not to touch the test substances.
3) Position the test on the patient's back - the outer part of the upper arm can eventually be used.
Smooth gently outward toward the edges, making sure each allergen makes firm contact with the skin. The 2 panels are placed on each side a few cm from the midline.

4) Indicate on the skin the location of the two notches on each panel with a medical marking pen.

The test should be applied on a healthy skin, free from scars, acne, dermatitis, or any other condition which may interfere with interpretation of test reactions (see section 4.4).

The patient should wear TRUE Test 24 for 48 hours without removing it and being careful not to get the test area wet (water, sweat).

Following this period, the test is removed. The reaction should be read 1/2 an hour after removal of the test and again 1-2 days after removal, when the allergic reactions are fully developed and mild irritant reactions have faded.

Neomycin sulphate and p-phenylenediamine, however sometimes cause reactions, which may not appear until 4-5 days after the application. Patients should be instructed to report this. If appropriate, an additional office visit with a late reading at day 5-7 will verify a late reaction.

Reading of the test should be done by the doctor.

Interpretation


An identification template is provided with each package of TRUE Test 24 for quick identification of any allergen, which causes a reaction. To assure correct positioning, marks on the skin should correlate with the notches on the template. Notice the difference between page 1 and 2 on the template corresponding to panel 1 and 2.

The interpretation method recommended by the International Contact Dermatitis Research Group is: -          Negative reaction
?          Doubtful reaction; faint macular erythema, none or insignificant infiltration +          Weak (nonvesicular) positive reaction; erythema, weak infiltration, possible papules ++         Strong (vesicular) positive reaction; erythema, infiltration, papules, vesicles +++        Extreme positive reaction: intense erythema, infiltrate, coalescing vesicles IR         Irritant reaction of different types
NT         Not tested


Note
•       Patients showing a negative reaction may still be sensitised to another substance not included in this test panel. Furthermore, false-negative results may occur. Retesting or testing with complementary substances may be indicated.

•    A positive reaction should meet the criteria for an allergic reaction (papular or vesicular erythema and infiltration).

•    Pustules, as well as patchy follicular or homogeneous erythema without infiltration are usually signs of irritation and do not indicate allergy.

What is important in evaluation a positive test response is not the number of plusses assigned to the test response, but determining whether the response is a truly positive reaction (caused by allergy) or a non-specific irritant reaction.

Paediatric use:
TRUE Test 24 is recommended for use in adults only, as safety and effectiveness of TRUE Test 24 in children has not been established.