Interactions : אינטראקציות

4.5 Interactions with other medicinal products and other forms of interaction
Concurrent use of povidone-iodine and hydrogen peroxide, enzymatic or silver- and taurolidine-containing wound healing agents or antiseptics leads to reduced effectiveness of both.

Using Betadine Gargle together with taurolidine should be avoided, as taurolidine may be converted to formic acid which causes painful burning.

Povidone-iodine must not be used in combination with mercury-containing preparations, since this may lead to the formation of corrosive mercury iodide.

Povidone-iodine must not be used in combination with octenidine-based antiseptics, as this may lead to temporary dark discolorations.

The povidone-iodine-complex is effective at a pH between 2.0 and 7.0. It can be expected that povidone-iodine will react with proteins and various other organic substances, such as components of the blood or pus, which would reduce efficacy.
This may be compensated for with a higher povidone-iodine dose.

Long-term use and especially use on large areas should be avoided in patients on lithium therapy, as high amounts of iodine could be resorbed. In exceptional cases this may induce (temporary) hypothyroidism. In such specific situations, a synergistic effect with the similar potential adverse effect of lithium may occur.

Effect on diagnostic tests:
Use of povidone-iodine may reduce iodine uptake of the thyroid. This may lead to errors in various assays (thyroid scintigraphy, PBI (protein-bound iodine) determination, radioiodine diagnostics) and may prevent any planned radioiodine therapy of the thyroid.
A waiting period of 1-2 weeks after discontinuation of the treatment with povidone- iodine should be observed.

Various diagnostic tools may provide false positive results due to the oxidizing effect of povidone-iodine (among others, toluidine and guaiac resin for the determination of hemoglobin and glucose in stool and urine).