Overdose : מינון יתר

4.9. Overdose
Povidone-iodine There are reports in the literature regarding symptoms of intoxication due to oral administration of more than 10 g of povidone-iodine.
These symptoms are: abdominal pain and cramping, nausea, vomiting, diarrhea, dehydration, hypotension with tendency to collapse, edema of the glottis, tendency to bleed (mucous membranes, kidneys), cyanosis, kidney damage including anuria, paresthesia, fever and pulmonary edema.
Long-term excessive intake of iodine may lead to symptoms of hyperthyroidism, tachycardia, restlessness, tremor and headaches.

Ethanol:
Oral administration of the concentrated solution may lead to symptoms of ethanol intoxication due to the ethanol content.

Treatment in case of overdose:
Povidone-iodine
Immediate administration of food rich in starch and protein (such as corn starch in water or milk). If necessary, gastric lavage with 5 % sodium thiosulfate solution (or 10 ml sodium thiosulfate I.V) every three hours.
Toxic iodine levels after resorption in the serum may be reduced efficiently using peritoneal dialysis or hemodialysis.
Thyroid function should be monitored closely, especially in high-risk groups, to rule out possible iodine-induced hyperthyroidism or aimed at an early detection.

Additional treatments depend on other symptoms, which may occur, such as metabolic acidosis and renal dysfunction.


Ethanol: Therapy for ethanol intoxication follows known clinical rules.