Contraindications : התוויות נגד

4.3     Contraindications
PK-Merz 100 mg film-coated tablets must not be used in patients with: - hypersensitivity to amantadine compounds, Yellow-orange lacquer (E 110) or to any of the excipients of the medicinal product
- severe decompensated heart failure (NYHA class IV)
- cardiomyopathies and myocarditis nd       rd
- 2 or 3 degree AV block
- existing bradycardia under 55 beats/min

- known prolonged QT interval (Bazett QTc > 420 ms) or discernible U-waves or congenital QT syndrome in the family anamnesis
- history of serious ventricular arrhythmias including torsade de pointes - simultaneous treatment with budipine or other drugs that prolong the QT interval (see section 4.5 ).
- reduced levels of potassium or magnesium in the blood


PK-Merz 100 mg film-coated tablets may be used only with particular caution in patients with: - prostatic hypertrophy
- narrow-angle glaucoma
- renal insufficiency (of varying severity; there is a risk of accumulation due to deterioration in renal filtration performance, see also sections 4.2 and 4.4)
- states of agitation or confusion
- delirious syndromes or exogenous psychosis in the anamnesis
- simultaneous treatment with memantine (see section 4.5).