Posology : מינונים

4.2.   Posology and method of administration

Posology
The recommended dosage for subjects over the age of 15 is 0.5 ml.
The initial protection is obtained after one single injection.
In order to obtain a long-term protection against infections caused by the Hepatitis A virus, in adolescents over the age of 15 and in adults, a booster dose should be administered, preferably between 6 and 12 months after the first vaccination and can be administered up to 36 months after the first vaccination (see section 5.1). It is estimated that HAV antibodies persist several years (at least 10 years) after the second dose (booster).

This vaccine can also be administered as a booster dose of the Hepatitis A vaccination in subjects over the age of 15 who have received the first injection with the combined Typhoid Fever (Vi purified polysaccharide) and Hepatitis A (inactivated) vaccine between 6 and 36 months earlier.


Method of administration
Because the vaccine is adsorbed, it is recommended to administer this vaccine by the intramuscular route (IM) to minimise local reactions.
The recommended injection site is the deltoid muscle.
In exceptional cases, the vaccine may be administered by the subcutaneous route in patients suffering from thrombocytopenia or in patients at risk of haemorrhage.
The vaccine is not to be injected into the buttocks because of the variability of this anatomical site (presence of varying amounts of adipose tissue), nor administered intradermally, since these methods of administration may induce a weaker immune response.
Do not inject by the intravascular route: ensure that the needle does not penetrate a blood vessel. This vaccine must not be mixed with other vaccines in the same syringe.