Overdose : מינון יתר

4.9     Overdose

Treatment with HMG can lead to a hyperstimulation of the ovaries which, however, in most cases becomes clinically relevant only after the administration of HCG for the purpose of triggering ovulation (see section 4.8 Undesirable effects).

With mild hyperstimulation (grade I) with mild ovarian enlargement (ovarian size 5 - 7 cm), with excessive steroid secretion and abdominal problems, no therapy is required. However, the patient is to be informed and thoroughly followed up. With hyperstimulation (grade II) with ovarian cysts (ovarian size 8 - 10 cm), abdominal symptoms, nausea and emesis, clinical monitoring and symptomatic treatment or, if necessary, intravenous volume substitution with higher hemoconcentration is indicated. With severe hyperstimulation (grade III) with large ovarian cysts (ovarian size > 10 cm), ascites, hydrothorax, distended abdomen, abdominal pain, dyspnea, salt retention, hemoconcentration, increased blood viscosity and increased platelet aggregation with the danger of thromboembolism, admission to hospital is inevitable, since life-threatening conditions could arise, making intensive medical measures necessary.