Posology : מינונים

4.2 Posology and method of administration

Chronic peripheral arterial occlusive disease at Fontaine stage IIb (intermittent claudication)
Unless otherwise prescribed, 1 Trental 400 mg prolonged-release tablet three times daily (equivalent to 1,200 mg pentoxifylline per day).

Special dosage instructions may be necessary for patients with low or fluctuating blood pressure levels.

In patients with impaired renal function (creatinine clearance less than 30 ml/min), the dose should be titrated to 50–70% of the standard dose, depending on individual tolerability, e.g.
by taking 400 mg pentoxifylline twice daily instead of 400 mg pentoxifylline three times a day.

In the case of patients with severe hepatic dysfunction, a dose reduction is required, which should be decided by the doctor on an individual basis according to the severity of the illness and tolerability.

Inner ear dysfunction caused by circulatory disorders (including hardness of hearing, sudden hearing loss).
Unless otherwise prescribed, 1 Trental 400 mg prolonged-release tablet twice daily or three times a day (equivalent to 800–1,200 mg pentoxifylline per day).

In cases of severe circulatory disturbances, a combination with parenterally administered Trental 100 mg or 300 mg ampoules (IV infusion) can accelerate the onset of action The total daily dose (parenteral + oral) should essentially not exceed 1,200 mg pentoxifylline.
Depending on the severity of symptoms, oral-only treatment, combined oral-parenteral treatment (IV infusion) or parenteral-only treatment (IV infusion) can be administered.

Method and duration of administration
The prolonged-release tablets should be swallowed whole (without chewing) with plenty of liquid following a meal. Duration of use must be tailored to the individual clinical condition and is decided by the doctor.
Note:
In the case of accelerated gastro-intestinal passage (laxatives, diarrhoea, surgical shortening of the intestine), elimination of tablet residues can occur in isolated cases. If premature elimination occurs only now and again, no importance need be attributed to the process.