Special Warning : אזהרת שימוש

4.4   Special Warnings and precautions for use

At the first signs of an anaphylactic/anaphylactoid reaction, Trental 400 must be discontinued immediately, and a physician must be informed.

Particular careful monitoring is required:
In patients with cardiac arrhythmias, hypotension or severe coronary artery disease following a heart attack or postoperatively following surgical interventions, Trental 400 should be used with caution, as a transient hypotensive effect is possible and, in isolated cases, might result in a reduction in coronary artery perfusion.

In patients with systemic lupus erythematosus (SLE) or mixed connective tissue disease, pentoxifylline should only be used after careful assessment of the risks and benefits.

Due to the risk of aplastic anaemia during treatment with pentoxifylline, the blood count should be regularly monitored.

Particularly careful monitoring is required in patients with impaired renal function. In patients with a creatinine clearance of less than 30 ml/min it may be necessary to reduce the daily dose of Trental 400 to one or two tablets to avoid accumulation. In patients with severely impaired liver function the dosage may need to be reduced.

In patients treated concomitantly with pentoxifylline and anti-vitamin K or platelet aggregation inhibitors (see also section 4.5).

In patients treated concomitantly with pentoxifylline and antidiabetic agents (see also section 4.5).
In patients treated concomitantly with pentoxifylline and ciprofloxacin (see also section 4.5).

In patients treated concomitantly with pentoxifylline and theophylline (see also section 4.5).

Effects on Driving

4.7 Effects on ability to drive and use machines

No effect known