Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1 Pharmacodynamic properties
Pharmacotherapeutic group: Fixed combination of antibiotic and corticosteroid ATC code: A01AB13 and A01AC01 "Stomatological preparations/Antiinfectives and antiseptics for local oral treatment/tetracylines" (A01AB13) and "Stomatological preparations/Corticosteroids for local oral treatment/triamcinolone" (A01AC01).
As active substances, Ledermix Paste contains triamcinolone acetonide (a powerful anti- inflammatory glucocorticoid) and demeclocycline (a broad-spectrum antibiotic). Clinical effect: Rapid pain relief for acute inflammatory conditions of the pulp and periodontium.
Demeclocycline is a broad-spectrum antibiotic of the tetracycline series and has bacteriostatic activity against tetracycline-sensitive Gram-positive and Gram-negative pathogens, as well as against Chlamydia spp., Mycoplasma spp., spirochaetes and Rickettsia spp. This includes both extracellular and intracellular pathogens. The mechanism of action is based on inhibition of bacterial ribosomal protein synthesis.
Triamcinolone acetonide is a fluorinated glucocorticoid with marked anti-allergic, anti- inflammatory and membrane-stabilising properties. Compared with cortisol, triamcinolone acetonide shows 160-fold greater glucocorticoid activity with practically non-existent mineralocorticoid activity. In topical cutaneous use, the following glucocorticoid effects on dermal cell systems have been described: inhibition of epidermis cell proliferation, reduced collagen synthesis, inhibited lymphocyte and granulocyte migration and proliferation, respectively, stabilisation of mast cell membranes, vasoconstriction of cutaneous vessels, inhibited pigment formation in melanocytes, inhibition of adipose cell proliferation.

Pharmacokinetic Properties

5.2 Pharmacokinetic properties
In in vitro studies on extracted teeth with radiolabelled tetracyclines versus triamcinolone acetonide, both substances diffused in small quantities through root and crown dentine, 
depending on the number of dentinal tubules. Both substances were released in minimal concentrations (in the nMol range) over a period of days to weeks.