Posology : מינונים

4.2 Posology and method of administration
Posology
The dosage depends on the nature and scope of use.

Paediatric population
Insufficient data are available for use in children (aged 3 years and older) (see section 4.4).

Method of administration
A: Cases of pulpitis, with exposure of the pulp
Practical procedure:
1st session: If after preparing the cavity and creating the extension and retention element, removal of the carious dentine close to the pulp has resulted in exposure of the pulp, carefully clean the cavity and pulp wound (H2O2 3% or physiological NaCl solution). Squeeze a small amount of Ledermix Paste onto a small pellet of cotton wool or felt and apply to the exposed pulp. Seal the cavity with ZnO eugenol or another, tightly sealing, temporary cavity filling material.
2nd session (two to three days later): Vitality test, remove the temporary filling and pellet. Clean the cavity and pulp wound (H2O2 3% or physiological NaCl solution). Inspect the pulp wound. If necessary, local anaesthesia. Cap the exposed pulp. Then perform underfilling and final cavity filling in the same session.

B: Cases of pulpitis with closed pulp cavity.
As exposure of the inflamed pulp represents an inherent drawback in terms of preserving its vitality, attempts should be made to avoid such exposure by observing the principles of indirect capping. Then place the final filling. The same approach as for pulpitis prophylaxis is recommended for so-called “traumatic pulpitis”.
Important note
Suppression of the inflammatory mechanism by the glucocorticoid is inherently associated with a temporary reduction in the connective tissue activity of the pulp. If the pulp is exposed, care should therefore be taken to ensure that Ledermix Paste, a water-soluble preparation, does not remain on the dental pulp for too long (see under A above). If the water-soluble preparation is left in place unchecked or if the temporary filling is not hermetically sealed, there is a danger of pulp necrosis or the development of chromic pulpitis.
C: Cases of periodontitis
Both for primary acute periodontitis secondary to total purulent pulpitis and for acute episodes of chronic periodontitis, prepare the canal as far as the apex during the first session (mechanical and chemical preparation: Na hypochlorite, H2O2), dry and fill with Ledermix Paste, using a spiral plugger (lentulo). In the second session (approximately 1 week later), flush Ledermix Paste out of the canal (H2O2) and complete the gangrene treatment in accordance with one of the recognised methods. If there are signs of periodontic irritation (especially after the canal has been widened), during the course of root canal treatment, insert Ledermix Paste into the cleaned canal with a rotating motion and leave in place for about 1 week. In the next session, remove Ledermix Paste from the canal and, after an inert temporary filling, complete the root treatment.