Pregnancy & Lactation : הריון/הנקה

4.6 Fertility, pregnancy and lactation
Pregnancy
Ledermix Paste should not be used during pregnancy. Use of triamcinolone, particularly in the first 5 months of pregnancy, should be withheld, as animal trials have revealed indications of teratogenic effects and there are no available data on the safety of use in humans during this period. In long-term use, intrauterine growth disturbances cannot be excluded. For foetuses, there is a danger of adrenal cortex atrophy with treatment at the end of pregnancy.
Due to the antianabolic effect and teratogenic effects – including deposition in bones and teeth – demeclocycline should preferably not be used during pregnancy and breast-feeding.

Breast-feeding
Glucocorticoids are excreted in human milk. Breast-feeding should be discontinued if treatment with higher doses or long-term therapy is required. Demeclocycline penetrates the placenta barrier and is excreted in human milk. Due to the antianabolic effect and teratogenic effects – including deposition in bones and teeth – demeclocycline should preferably not be used during breast-feeding.

Fertility
No data are available on the effect of Ledermix Paste on fertility.