Interactions : אינטראקציות

4.5     Interaction with other medicinal products and other forms of interaction

No interaction studies have been performed in humans.
Other photosensitising agents

It is possible that concomitant use of other photosensitising medicinal products (e.g., tetracyclines, sulphonamides, phenothiazines, sulfonylurea, hypoglycaemic medicinal products, thiazide diuretics, and griseofulvin) could increase the potential for photosensitivity reactions. Caution should therefore be exercised when using Visudyne concomitantly with other photosensitising medicinal products (see “Photosensitivity and exposure to light” under section 4.4).

Agents which increase verteporfin uptake in the vascular endothelium

Agents such as calcium channel blockers, polymixin B, and radiation therapy are known to alter the vascular endothelium. Based on theoretical data and despite the lack of clinical evidence, these agents might result in enhanced verteporfin tissue-uptake when used concurrently.

Free radical scavengers

Although there is no clinical evidence, theoretical data suggest that antioxidants (e.g., beta-carotene) or medicinal products which scavenge free radicals (e.g., dimethylsulfoxide (DMSO), formate, mannitol or alcohol) might quench the activated oxygen species generated by verteporfin, resulting in decreased verteporfin activity.

Medicinal products which antagonise blood vessel occlusion

Since blood vessel occlusion is the major mechanism of verteporfin action, there is a theoretical possibility that agents such as vasodilators and those which diminish clotting and platelet aggregation (e.g., thromboxane A2 inhibitors) can antagonise the action of verteporfin.