Posology : מינונים

4.2    Posology and method of administration

Therapy should be initiated by a physician experienced in the management of HIV infection.
Posology

Efavirenz must be given in combination with other antiretroviral medicines (see section 4.5).

In order to improve the tolerability of nervous system adverse reactions, bedtime dosing is recommended (see section 4.8).

Adults
The recommended dose of efevirenz in combination with nucleoside analogue reverse transcriptase inhibitors (NRTIs) with or without a PI (see section 4.5) is 600 mg orally, once daily.

Drug interaction
As STOCRIN 600 mg tablet is the only dose form available in the local marketplace, the recommended dose adjustments for voriconazole and rifampicin are not possible (see section 4.5) 
Special populations

Renal impairment
The pharmacokinetics of efavirenz have not been studied in patients with renal insufficiency; however, less than 1 % of an efavirenz dose is excreted unchanged in the urine, so the impact of renal impairment on efavirenz elimination should be minimal (see section 4.4).

Hepatic impairment

Patients with mild liver disease may be treated with their normally recommended dose of efavirenz.
Patients should be monitored carefully for dose-related adverse reactions, especially nervous system symptoms (see sections 4.3 and 4.4).

Paediatric population (3 to 17 years)
Due to the local marketplace availability of 600 mg tablets only, this medication can only be administered to children weighing greater than 40kg.

Method of administration

It is recommended that STOCRIN be taken on an empty stomach. The increased efavirenz concentrations observed following administration of STOCRIN with food may lead to an increase in frequency of adverse reactions (see sections 4.4 and 5.2).