Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Observed Interactions resulting in a contraindication
Potassium-sparing diuretics:
Concomitant treatment with potassium-sparing diuretics (spironolactone, triamterene, amiloride) is contraindicated (see also section 4.3 Contraindications). Drugs which interfere with potassium excretion may promote hyperkalemia when given together with Slow-K.
Anticipated interactions resulting in concomitant use not being recommended Drugs causing hyperkalemia:
Slow-K should be used with caution in patients receiving any drug known to have a potential for hyperkalemia, such as ACE inhibitors, angiotensin-II-receptor- antagonists, NSAIDs (e.g. indomethacin), beta-blockers, heparin, digoxin ciclosporin (see also section 4.4 Special warnings and precautions for use).
Interactions to be considered
Drugs causing hyperkalemia:
Other drugs such as direct renin inhibitors (e.g. aliskerin) and proton pump inhibitors can cause hyperkalemia when used concomitantly with Slow-K. Thus, caution should be exercised in their concomitant use.
Anticholinergics:
Since anticholinergic drugs may reduce gastrointestinal motility, they should be prescribed with great care when given concomitantly with solid oral potassium preparations, particularly in high dosage (see also section 4.4 Special warnings and precautions for use).