Adverse reactions : תופעות לוואי

Adverse Reactions
Abdominal colic and flatulence may occur.
Skin rashes or eruptions may appear in individuals sensitive to phenolphthalein.
Cardiac distress has occurred with phenolphthalein use.
Respiratory distress has occurred with the use of phenolphthalein.
Precautions
Patients should be advised to drink liberally when using laxatives to aid stool softening.
Because of enterohepatic circulation of phenolphthalein, the laxative effects of this preparation may continue for several days.
If a skin rash or any other hypersensitivity reaction occurs, treatment should be discontinued.
Because of the presence of belladonna, even in a small quantity, caution should be exercised in patients with glaucoma, pyloric stenosis, obstructive uropathy, and in conditions characterized by tachycardia.
Because of the phenolphthalein and anthraquinone components, this preparation may impart a pink to reddish color to alkaline urine. Patients should be warned accordingly.
Prolonged use of laxatives may cause dependence for bowel function.
Gastric ulcer may produce a delay in gastric emptying time and may complicate therapy (antral stasis), due to the belladonna content.
Caution should be exercised when this medicine is administered to patients with hyperthyroidism, since belladonna may increase the tachycardia caused by this disorder.

LAXATIVE COMPOUND ,     8. 9. 2011, RH


Drug Interactions
Laxative-induced diarrhea may interfere with the full absorption of many drugs. It would therefore be prudent to ensure an adequate interval of time (at least 2 hours), between the ingestion of laxatives and other drugs (including antacids).In the case of oral contraceptives, it is recommended to use additional precautionary measures.

Hypokalaemia (resulting from long-term laxative abuse) potentiates the action of cardiac glycosides and interacts with antiarrhythmic medicinal products, with medicinal products, which induce reversion to sinus rhythm (e.g. quinidine) and with medicinal products inducing QT-prolongation. Concomitant use with other medicinal products inducing hypokalaemia (e.g. diuretics, corticosteroids and liquorice root) may enhance electrolyte imbalance.

Diagnostic Interference
Phenolphthalein and anthraquinones may interfere with Acetest and Ketostix qualitative tests for ketones in urine, by producing a pink to reddish color in alkaline urine.