Special Warning : אזהרת שימוש

Warnings
If laxatives are needed every day the cause of the constipation should be investigated. Long-term use of laxatives should be avoided.
If stimulant laxatives are taken for longer than a brief period of treatment, this may lead to impaired function of the intestine and dependence on laxatives, and also to electrolyte imbalance.
Patients with kidney disorders should be aware of possible electrolyte imbalance.

LAXATIVE COMPOUND ,         8. 9. 2011, RH
If symptoms worsen or do not improve after 7 days, contact a doctor.

Abuse of Laxatives
Typical symptoms of Laxative abuse include abdominal pain, weakness, fatigue, thirst, vomiting, edema, bone pain (due to osteomalacia), fluid and electrolyte imbalance, hypoalbuminemia (due to protein-losing gastroenteropathy), and syndromes that mimic colitis. If the bowel has not been permanently damaged, it may require several months to retain the bowel without the assistance of laxatives.

Belladonna alkaloids may produce a delay in gastric emptying (antral stasis) which would complicate the management of gastric ulcer.Theoretically, with overdosage, a curare-like action may occur.
In the presence of a high environmental temperature, heat prostration can occur with belladonna alkaloids (fever and heatstroke due to decreased sweating).
Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. In this instance treatment with this drug would be inappropriate and possibly harmful.

Use in Pregnancy
Safety of use in pregnancy has not been established. Therefore this drug should not be used during pegnancy.

Use in Breastfeeding
Phenolphthalein appears in breast milk. Use during breastfeeding is not recommended.

Use in Pediatrics
Not to be used in children under 12 years of age.

Adverse Reactions
Abdominal colic and flatulence may occur.
Skin rashes or eruptions may appear in individuals sensitive to phenolphthalein.
Cardiac distress has occurred with phenolphthalein use.
Respiratory distress has occurred with the use of phenolphthalein.
Precautions
Patients should be advised to drink liberally when using laxatives to aid stool softening.
Because of enterohepatic circulation of phenolphthalein, the laxative effects of this preparation may continue for several days.
If a skin rash or any other hypersensitivity reaction occurs, treatment should be discontinued.
Because of the presence of belladonna, even in a small quantity, caution should be exercised in patients with glaucoma, pyloric stenosis, obstructive uropathy, and in conditions characterized by tachycardia.
Because of the phenolphthalein and anthraquinone components, this preparation may impart a pink to reddish color to alkaline urine. Patients should be warned accordingly.
Prolonged use of laxatives may cause dependence for bowel function.
Gastric ulcer may produce a delay in gastric emptying time and may complicate therapy (antral stasis), due to the belladonna content.
Caution should be exercised when this medicine is administered to patients with hyperthyroidism, since belladonna may increase the tachycardia caused by this disorder.

LAXATIVE COMPOUND ,     8. 9. 2011, RH


Effects on Driving