Posology : מינונים

4.2 Posology and method of administration
Clodronate is mainly eliminated via the kidneys. Therefore, adequate fluid intake must be maintained during clodronate treatment.

Pediatric patients: Safety and efficacy in children have not been established.
Elderly patients:
There are no special dosage recommendations for the elderly. Clinical trials have included patients over 65 years and no adverse effects specific to this age group have been reported.


Bonefos tablets should be swallowed whole. A Bonefos 800 mg tablet may be divided into two to ease swallowing, but the halves have to be taken at the same time of administration. Bonefos tablets must not be crushed or dissolved before intake.

A daily dose of 1600 mg should be taken as a single dose. When higher daily doses are used, the part of the dose exceeding 1600 mg should be taken separately (as a second dose) as recommended below.
The single daily dose and the first dose of two, should preferably be taken in the morning on an empty stomach together with a glass of water. The patient should then refrain from eating, drinking (other than plain water), and taking any other oral drugs for one hour.


When twice daily dosing is used the first dose should be taken as recommended above. The second dose should be taken between meals, more than two hours after and one hour before eating, drinking (other than plain water), or taking any other drugs.


Clodronate should in no case be taken with drinks, food or drugs containing calcium or other divalent cations because they impair the absorption of clodronate.


Adult patients with normal renal function:
Treatment of hypercalcemia due to malignancy:

Intravenous clodronate treatment is recommended for the start of treatment in hypercalcemia. Subsequently, an oral dosage of 1600–3200 mg clodronate daily may be used. However, if oral therapy is used, a high starting dose of 2400 -3200 mg should be used and, depending on the individual response,
this can be reduced gradually to 1600 mg daily..

Treatment of osteolysis due to malignancy:

When oral therapy is used to treat increased bone resorption without hypercalcemia the recommended starting dose is 1600 mg daily. If clinically necessary, the dose may be increased, but is not recommended to exceed 3200 mg daily.

Patients with renal failure:

Clodronate is eliminated mainly via the kidneys. Therefore, it should be used with caution in patients with renal failure; Daily doses exceeding 1600 mg should not be used continuously.
It is recommended that the clodronate dosage be reduced as follows: 

Creatinine Clearance, Dose
Renal insufficiency      ml/min
Mild                     50-80 ml/min               1600 mg/daily (no need to reduce the dose)
Moderate                 30-50 ml/min               1200 mg/daily Severe*                  <10-30 ml/min              800 mg/daily *) No pharmacokinetic data are available in patients with renal failure with creatinine clearance below 10 ml/min for oral clodronate.
Bonefos tablets are contraindicated in patients with severe renal failure (creatinine clearance below 10ml/min),