Adverse reactions : תופעות לוואי

4.8 Undesirable effects
The following definitions apply to the frequency terminology used hereafter: Very common ( 1/10)
Common ( 1/100, < 1/10)
Uncommon ( 1/1,000, < 1/100)
Rare ( 1/10,000, < 1/1,000)
Very rare (< 1/10,000)

Cardiac disorders:
Very common: bradycardia.
Common: worsening of heart failure.
Uncommon: AV-conduction disturbances.

Investigations:
Rare: increased triglycerides, increased liver enzymes (ALAT, ASAT).
Nervous system disorders:
Common: dizziness, headache.
Rare: syncope

Eye disorders:
Rare: reduced tear flow (to be considered if the patient uses lenses).
Very rare: conjunctivitis.

Ear and labyrinth disorders:
Rare: hearing disorders.
Respiratory, thoracic and mediastinal disorders:
Uncommon: bronchospasm in patients with bronchial asthma or a history of obstructive airways disease.
Rare: allergic rhinitis.

Gastrointestinal disorders:
Common: gastrointestinal complaints such as nausea, vomiting, diarrhoea, constipation.

Skin and subcutaneous tissue disorders:
Rare: hypersensitivity reactions (itching, flush, rash).
Very rare: alopecia. Beta-blockers may provoke or worsen psoriasis or induce psoriasis- like rash.

Musculoskeletal and connective tissue disorders:
Uncommon: muscular weakness and cramps.

Vascular disorders:
Common: feeling of coldness or numbness in the extremities, hypotension.
Uncommon: orthostatic hypotension.
General disorders:
Common: asthenia, fatigue.

Hepatobiliary disorders:
Rare: hepatitis.

Reproductive system and breast disorders:
Rare: potency disorders.
Psychiatric disorders:
Uncommon: sleep disorders, depression.
Rare: nightmares, hallucinations.