Posology : מינונים

4.2 Posology and method of administration
The lowest dosage that will produce an acceptable result should be used (see section 4.4); when it is possible to reduce the dosage, this must be accomplished by stages. During prolonged therapy any intercurrent illness, trauma or surgical procedure will require a temporary increase in dosage; if corticosteroids have been stopped following prolonged therapy they may need to be temporarily re- introduced.
Adults: The dose used will depend upon the disease, its severity, and the clinical response obtained.
The following regimens are for guidance only. Divided dosage is usually employed.
Short-term treatment: 20mg (6.7ml) to 30mg (10ml) daily for the first few days, subsequently reducing the daily dosage by 2.5mg (0.8ml) or 5mg (1.67ml) every two to five days, depending upon the response.
Rheumatoid arthritis: 7.5mg (2.5ml) to 10mg (3.3ml) daily. For maintenance therapy the lowest effective dosage is used.
Most other conditions: 10mg (3.3ml) to 100mg (33.3ml) daily for one to three weeks, then reducing to the minimum effective dosage.
Children: Fractions of the adult dosage may be used (e.g. 75% at 12 years, 50% at 7 years and 25% at 1 year) but clinical factors must be given due weight.
Danalone may be given early in the treatment of acute asthma attacks in children. For children over 5 years use a dose of 30-40mg (10-13.3ml) prednisolone. For children aged 2-5 years use a dose of 20mg (6.7ml) prednisolone. Those already receiving maintenance steroid tablets should receive 2mg/kg prednisolone up to a maximum dose of 60mg (20ml). The dose of prednisolone may be repeated for children who vomit; but intravenous steroids should be considered in children who are unable to retain orally ingested medication. Treatment for up to three days is usually sufficient, but the length of course should be tailored to the number of days necessary to bring about recovery. There is no need to taper the dose at the end of treatment.
For children under 2 years, Danalone can be used early in the management of moderate to severe episodes of acute asthma in the hospital setting, at a dose of 10mg (3.3ml) for up to three days.