Interactions : אינטראקציות

4.5   Interactions with other medicinal products and other forms of Interaction
Anti-convulsant therapy: Danol may affect the plasma level of carbamazepine and possibly the patient's response to this agent and to phenytoin. With phenobarbital it is likely that similar interaction would occur.
Anti-diabetic therapy: Danol can cause insulin resistance.
Oral anti-coagulant therapy: Danol can potentiate the action of warfarin.
Anti-hypertensive therapy: Possibly through promotion of fluid retention, Danol can oppose the action of anti-hypertensive agents.
Ciclosporin and tacrolimus: Danol can increase the plasma level of ciclosporin and tacrolimus, leading to an increase of the renal toxicity of these drugs.
Concomitant steroids: Although specific instances have not been described, it is likely that interactions will occur between Danol and gonadal steroid therapy.
Migraine therapy: Danol may itself provoke migraine and possibly reduce the effectiveness of medication to prevent that condition.
Ethyl alcohol: Subjective intolerance in the form of nausea and shortness of breath has been reported.
Alpha calcidol: Danol may increase the calcaemic response in primary hypoparathyroidism necessitating a reduction in dosage of this agent.
Interactions with laboratory function tests: Danazol treatment may interfere with laboratory determination of testosterone or plasma proteins (See also section4.8 Undesirable effects) Statins: The risk of myopathy and rhabdomyolysis is increased by concomitant administration of danazol with statins metabolised by CYP3A 4.The concomitant administration of Danazol with simvastatin is contraindicated (see section 4.3).