Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1   Pharmacodynamic properties
Pharmacotherapeutic group: Sensory organ; ophthalmologicals; antibiotics ATC Code SO1AA12.
Mechanism of action
Tobramycin is actively transported across the bacterial cell membrane, and binds to a specific receptor protein on the 30 S subunit of bacterial ribosomes and interferes with an initiation complex between messenger RNA (mRNA) and the 30 S subunit, thus inhibiting protein synthesis.
Pharmacodynamic effects
Microbiology
In Vitro Data: in vitro studies have demonstrated tobramycin is active against susceptible strains of the following microorganisms:
• Staphylococci, including S. aureus and S. epidermidis (coagulase-positive and coagulase- negative), including penicillin-resistant strains.
• Streptococci, including some of the group A - beta-haemolytic species, some non- haemolytic species, and some Streptococcus pneumoniae.
• Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis (indole-negative) and indole- positive Proteus species.
Bacterial resistance may develop upon prolonged use.
Tobramycin is not effective against most strains of group D Streptococci.

Pharmacokinetic Properties

5.2     Pharmacokinetic properties
Not available.