Special Warning : אזהרת שימוש

4.4 Special warnings and precautions for use

At the first signs of an anaphylactic/anaphylactoid reaction, Oxopurin 400 must be discontinued immediately, and a physician must be informed.
Particular careful monitoring is required:
In patients with hypotension or severe coronary artery disease, Oxopurin 400 should be used with caution, as a transient hypotensive effect is possible and, in isolated cases, might result in a reduction in coronary artery perfusion.
Particularly careful monitoring is required in patients with impaired renal function. In patients with a creatinine clearance of less than 30 ml/min it may be necessary to reduce the daily dose of Oxopurin 400 to one or two caplets to avoid accumulation. In patients with severely impaired liver function the dosage may need to be reduced.
In patients treated concomitantly with pentoxifylline and anti-vitamin K or platelet aggregation inhibitors (see also section 4.5).
In patients treated concomitantly with pentoxifylline and antidiabetic agents (see also section 4.5).
In patients treated concomitantly with pentoxifylline and ciprofloxacin (see also section 4.5).
In patients treated concomitantly with pentoxifylline and theophylline (see also section 4.5).
Oxopurin 400 contains lactose. Patients with rare hereditary problems of galactose intolerance, ‎total lactase deficiency or glucose-galactose malabsorption should not take this medicine.‎

Effects on Driving

4.7 Effects on ability to drive and use machines

No effect known.