Posology : מינונים

4.2   Posology and method of administration
Adults
Evorel Conti is a continuous combined HRT preparation.
Evorel Conti TDSs should be applied individually without interruption. TDSs should be applied twice weekly, every three to four days, to the trunk below the waist.
Insufficient data are available to guide dose adjustments for patients with severe liver or kidney function impairment.

For treatment of post- menopausal symptoms, the lowest effective dose should be used. HRT should be continued only as long as the benefit in alleviation of severe symptoms outweighs the risks of HRT.
Should a TDS fall off, it should be replaced immediately with a new patch. However, the usual day of changing TDSs should be maintained.

Method of Administration
The Evorel Conti TDS should be placed on a clean, dry, healthy, intact area of skin, on the trunk of the body below the waist. Creams, lotions or powders may interfere with the adhesive properties of the patch. The TDS should not be applied on or near the breasts. The area of application should be changed, with an interval of at least one week allowed between applications to a particular site. The skin area selected should not be damaged or irritated. The waistline should not be used because excessive rubbing of the TDS may occur.
The TDS should be used immediately after opening the sachet. Remove one part of the protecting foil. Apply the exposed part of adhesive to the application site from the edge to the middle; avoid wrinkling of the TDS. The second part of the protective foil should now be removed and the freshly exposed adhesive applied. Wrinkling should again be avoided and the palm of the hand used to press the TDS onto the skin and to bring the TDS to skin temperature at which the adhesive effect is optimized.
The patient should avoid contact between fingers and the adhesive part of the TDS during application.
Should a patch fall off, a new patch should be applied immediately. However, the usual day of changing patches should be maintained. It is not necessary to remove the patch during bathing or showering. It is recommended, however, that the patch be removed prior to a sauna bath, and that a new patch is applied immediately thereafter.
Missed dose

If the patient forgets to change their patch, they should change it as soon as possible and apply the next one at the normal time. However, if it is almost time for the next patch, the patient should skip the missed one and go back to their regular schedule.
Only one patch should be applied at a time.
Forgetting a dose may increase the likelihood of break-through bleeding and spotting.
To remove the Evorel Conti TDS, peel away an edge of the patch and pull smoothly away from the skin. (See Instructions for Use and Handling, Section 6.6.) Any adhesive that remains on the skin after removal of Evorel Conti TDS may be removed washing with soap and water or by rubbing it off with the fingers.
Children
Evorel Conti is not indicated in children.

Elderly
Data are insufficient in regard to the use of Evorel Conti in the elderly (> 65 years old).

Route of administration
Transdermal use.