Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Uncommon        Thrombosis and phlebitis                          5. Pharmacological properties                                                                   In neonatal primates, exposure to 3 hours of an anaesthetic regimen that produced a RIPOL 20MG/ML has been used in association with spinal and epidural anaesthesia and                                                                                                                                                                                                         light surgical plane of anaesthesia did not increase neuronal cell loss, however, treatment Respiratory, thoracic and   Common          Transient apnoea during induction                 5.1 Pharmacodynamic properties with commonly used premedicants, neuromuscular blocking drugs, inhalational agents                                                                                                                                                                                                          regimens of 5 hours or longer increased neuronal cell loss. The clinical significance of and analgesic agents; no pharmacological incompatibility has been encountered. Lower          mediastinal disorders       Not known (9) Respiratory depression (dose dependent)             Pharmacotherapeutic group: Other general anaesthetics these nonclinical findings is not known, and healthcare providers should balance the doses of RIPOL 20MG/ML may be required where general anaesthesia is used as an                                                                                                              ATC code: N01AX10 Gastrointestinal disorders Common           Nausea and vomiting during recovery phase                                                                                                         benefits of appropriate anaesthesia in young children less than 3 years of age and adjunct to regional anaesthetic techniques. Profound hypotension has been reported                                                                                                          Mechanism of action                                                                             pregnant women who require procedures against the potential risks suggested by the following anaesthetic with propofol in patients treated with rifampicin.                                                  Very rare       Pancreatitis                                      Propofol (2, 6-diisopropylphenol) is a short-acting general anaesthetic agent with a rapid      preclinical data.
The concurrent administration of other CNS depressants such as pre-medication drugs,          Hepatobiliary disorders     Not known (9) Hepatomegaly (5)                                    onset of action of approximately 30 seconds. Recovery from anaesthesia is usually rapid.        Propofol is a drug on which extensive clinical experience has been obtained. All relevant inhalation agents and analgesic agents may add to the sedative, anaesthetic and                                                                                                             The mechanism of action, like all general anaesthetics, is poorly understood. However,          information for the prescriber is provided elsewhere in this document.
cardiorespiratory depressant effects of RIPOL 20MG/ML (see Section 4.4).                      Musculoskeletal and         Not known (9) Rhabdomyolysis (3), (5)                             propofol is thought to produce its sedative/anaesthetic effects by the positive modulation connective tissue                                                                                                                                                                             6. Pharmaceutical particulars A need for lower propofol doses has been observed in patients taking valproate. When                                                                                                        of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABAA disorders                                                                                     receptors.                                                                                      6.1 List of excipients used concomitantly, a dose reduction of propofol may be considered.
Renal and urinary           Very rare       Discolouration of urine following prolonged       Pharmacodynamic effects                                                                         Soybean oil, glycerol, egg phospholipids, sodium hydroxide and water for injection.