Interactions : אינטראקציות

9. DRUG INTERACTIONS
9.1 MAO-Inhibiting Drugs
Co-administration of Noradrenaline Kalceks with monoamine oxidase (MAO) inhibitors or other drugs with MAO- inhibiting properties (e.g., linezolid) can cause severe, prolonged hypertension.
If administration of Noradrenaline Kalceks cannot be avoided in patients who recently have received any of these drugs and in whom, after discontinuation, MAO activity has not yet sufficiently recovered, monitor for hypertension.

9.2 Tricyclic Antidepressants
Co-administration of Noradrenaline Kalceks with tricyclic antidepressants (including amitriptyline, nortriptyline, protriptyline, clomipramine, desipramine, imipramine) can cause severe, prolonged hypertension. If administration of Noradrenaline Kalceks cannot be avoided in these patients, monitor for hypertension.

9.3 Antidiabetics
Noradrenaline Kalceks can decrease insulin sensitivity and raise blood glucose. Monitor glucose and consider dosage adjustment of antidiabetic drugs.

9.4 Halogenated Anesthetics
Concomitant use of Noradrenaline Kalceks with halogenated anesthetics (e.g., cyclopropane, desflurane, enflurane, isoflurane, and sevoflurane) may lead to ventricular tachycardia or ventricular fibrillation. Monitor cardiac rhythm in patients receiving concomitant halogenated anesthetics.