Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1   Pharmacodynamic properties
Isoflurane is an inhalation-type anaesthetic, belonging to the group of halogenated anaesthetics. Induction and recovery from anaesthesia take place rapidly with Isoflurane.

Isoflurane has the slightly irritating odour of ether, which can limit the speed of induction.

Pharyngeal and laryngeal reflexes are rapidly diminished as a result of which tracheal intubation is rendered easy.

Pharmacokinetic Properties

5.2   Pharmacokinetic properties
Aerrane is metabolised minimally in comparison to other halogenated anaesthetics.
On average 95% of the Aerrane is recovered in the expired air; 0.2% of the Aerrane that is taken up within the body is metabolised. The principal metabolite is trifluoroacetic acid. The average serum level of inorganic fluoride in patients administered Aerrane anaesthesia is between 3 and 4 micromol/litre.

In patients anaesthetised with isoflurane, the mean serum concentration of inorganic fluorides is usually less than 5 micromol/litre and occurs about four hours after anaesthesia, returning to normal levels within 24 hours. This should not alter renal function in a normal subject.