Adverse reactions : תופעות לוואי

ADVERSE REACTIONS
There have been rare reports of anaphylactoid reactions following large intravenous doses of thiamine.
The risk, however, is negligible if thiamine is co-administered with other B vitamins. There have been no reports of fatal anaphylactoid reactions associated with pediatric multivitamin preparations.

There have been rare reports of the following types of reactions:
Dermatologic: rash, erythema, pruritus.
CNS: headache, dizziness, agitation, anxiety.
Ophthalmic: diplopia.
Allergic: urticaria, periorbital and digital edema.

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.
Any suspected adverse events should be reported to the Ministry of Health according to the National Regulation by using an online form http://forms.gov.il/globaldata/getsequence/getsequence.aspx?formType=AdversEffectMedic@moh.
gov.il


SYMPTOMS AND TREATMENT OF OVERDOSAGE
The fat-soluble vitamins A, D and E can accumulate to harmful levels. Water-soluble vitamins, however, are readily excreted in the urine. Treatment of vitamin overdosage usually consists of withdrawal of the vitamin.