Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1   Pharmacodynamic properties

Pharmacotherapeutic group: plasma substitutes and plasma protein fractions, albumin ATC code: B05A A01
Human albumin accounts quantitatively for more than half of the total protein in the plasma and represents about 10 % of the protein synthesis activity of the liver.
Physico-chemical data: Human Albumin 200 or 250 g/l has a corresponding hyperoncotic effect.
The most important physiological functions of albumin result from its contribution to oncotic pressure of the blood and transport function. Albumin stabilises the circulating blood volume and is a carrier of hormones, enzymes, medicinal products and toxins.

Pharmacokinetic Properties

5.2   Pharmacokinetic properties

Under normal conditions, the total exchangeable albumin pool is 4 - 5 g/kg body weight, of which 40 - 45 % is present intravascularly and 55 - 60 % in the extravascular space.
Increased capillary permeability will alter albumin kinetics and abnormal distribution may occur in conditions such as severe burns or septic shock.

Under normal conditions, the average half-life of albumin is about 19 days. The balance between synthesis and breakdown is normally achieved by feedback regulation. Elimination is predominantly intracellular and due to lysosomal proteases.

In healthy subjects, less than 10 % of infused albumin leaves the intravascular compartment during the first 2 hours following infusion. There is considerable individual variation in the effect on plasma volume. In some patients the plasma volume can remain increased for some hours. However, in critically ill patients, albumin can leak out of the vascular space in substantial amounts at an unpredictable rate.