Posology : מינונים

4.2       Posology and method of administration

Posology
Adults

Healing of duodenal ulcer, gastric ulcer and NSAID-induced peptic ulcer: 800 micrograms daily in two or four divided doses taken with breakfast and / or each main meal and at bedtime.

Treatment should be given initially for at least 4 weeks even if symptomatic relief has been achieved sooner. In most patients ulcers will be healed in 4 weeks but treatment may be continued for up to 8 weeks if required. If the ulcer relapses further treatment courses may be given.

Prophylaxis of NSAID-induced peptic ulcer: 200 micrograms twice daily, three times daily or four times daily. NSAIDs should be taken according to the schedule prescribed by the physician. When appropriate, misoprostol tablets should be taken simultaneously with NSAIDs.
Misoprostol should be taken for the duration of NSAID therapy. Treatment can be continued as required. Dosage should be individualised according to the clinical condition of each patient.

Use in Women of Childbearing Potential (see Section 4.1 – Therapeutic indications, Section 4.3 –
Contraindications, Section 4.4 -Special warnings and precautions for use and 4.6 –Pregnancy and lactation)

Renal impairment:
Dosage may need to be reduced in patients with renal failure, (See section 5.2 Pharmacokinetic properties, Impaired Renal Function


Hepatic impairment: Cytotec® is metabolised by fatty acid oxidising systems present in organs throughout the body. Its metabolism and plasma levels are therefore unlikely to be affected markedly in patients with hepatic impairment.
Elderly

The usual dosage may be used.
Paediatric population
Use of Cytotec® in children under the age of 18 has not yet been evaluated in the treatment of peptic ulceration or NSAID-induced peptic ulcer disease.