Interactions : אינטראקציות

4.5. Interactions with other medicinal products and other forms of interaction
Drug interactions
Metformin


In diabetic patients, intra-arterial administration of LIPIODOL ULTRA-FLUID is likely to cause lactic acidosis triggered by functional renal failure. For patients scheduled to undergo embolisation or Trans- Arterial Chemo-Embolisation, metformin treatment should be suspended 48 hours before the procedure and should only be resumed 2 days after the procedure.
Combinations to be taken into consideration
+    Beta-blockers, vasoactive substances, angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists.
These medicinal products lead to a decrease in the effectiveness of the cardiovascular mechanisms that compensate for blood-pressure disturbances: the doctor must be informed before the administration of LIPIODOL ULTRA-FLUID and have resuscitation equipment to hand.
+    Diuretics
Since diuretics are likely to cause dehydration, the risk of acute renal failure is increased, particularly when contrast agents are administered at high doses.
Precautions for use: rehydration before intra-arterial administration of LIPIODOL ULTRA-FLUID for embolisation.
+    Interleukin ll
There is a risk of increased reaction to contrast agents in case recent treatment with interleukin-ll (intravenous route): rash or, more rarely, hypotension, oliguria, and even renal failure.
Interference with diagnostic tests
Since LIPIODOL ULTRA-FLUID remains in the body for several months, results of thyroid diagnostic tests may be distorted for up to two years after a lymphography.