Posology : מינונים

4.2 Posology and method of administration

Solution for infusion after mixture with a compatible infusion solution.
Solutions of mixtures with an osmolarity above 800 mosmol/l should be infused by the central venous route.
Adults
Dosage depends on the severity of the catabolic state and on amino acid requirement.
A maximum daily dosage of 2 g amino acids/kg body weight should not be exceeded in parenteral nutrition. The supply of alanine and glutamine via Dipeptiven should be taken into consideration in the calculation; the proportion of the amino acids supplied through Dipeptiven should not exceed approx. 20% of the total supply.

Daily dose
1.5 - 2.0 ml of Dipeptiven per kg body weight (equivalent to 0.3 - 0.4 g N(2)-L-alanyl-L-glutamine per kg body weight). This equates to 100 to 140 ml Dipeptiven for a patient of 70 kg body weight.

Maximum daily dose: 2.0 ml equivalent to 0.4 g N(2)-L-alanyl-L-glutamine of Dipeptiven per kg body weight.

The following adjustments thus result for the amino acid supply through the carrier solution: Amino acid requirement 1.5 g/kg body weight per day:
1.2 g amino acids + 0.3 g N(2)-L-alanyl-L-glutamine per kg body weight 
Amino acid requirement 2 g/kg body weight per day:
1.6 g amino acids + 0.4 g N(2)-L-alanyl-L- glutamine per kg body weight.

Dipeptiven is an infusion solution concentrate which is not designed for direct administration.
Patients with total parenteral nutrition
The rate of infusion depends on that of the carrier solution and should not exceed 0.1 g amino acids/kg body weight per hour.
Dipeptiven should be mixed with a compatible amino acid carrier solution or an amino acid containing infusion regimen prior to administration.

Duration of administration
The duration of use should not exceed 3 weeks.
Paediatric population
Safety and efficacy in children have not been established.