Interactions : אינטראקציות

4.5.   Interaction with other medicinal products and other forms of interaction
4.5.1. Medicinal products
+ Metformin in diabetics (see Section 4.4 Precautions for use — renal insufficiency).
+ Radiopharmaceuticals (see Section 4.4 Warnings)
Iodinated contrast agents disrupt radioactive iodine uptake by thyroid tissue for several weeks, which may lead to impaired uptake in thyroid scintigraphy and decreased efficacy of iodine 131 treatment.
In patients due to undergo renal scintigraphy with injection of a radiopharmaceutical secreted by the renal tubules, it is preferable to carry out the scintigraphy before iodinated contrast agent injection.
+ Beta blockers, vasoactive substances, angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists.
These medicinal products lead to a decrease in the efficacy of the cardiovascular compensatory mechanisms for blood pressure disorders: the doctor must be informed before the injection of iodinated contrast agent and have resuscitation equipment to hand.
+ Diuretics
Due to the risk of diuretic-induced dehydration, prior rehydration with fluids and electrolytes is necessary to limit the risk of acute renal failure.


+ Interleukin 2
There is a risk of increased reaction to contrast agents following recent treatment with interleukin 2 (intravenous route): rash or, more rarely, hypotension, oliguria, or even renal failure.

4.5.2. Other forms of interaction
High concentrations of iodinated contrast agent in plasma and urine may interfere with in vitro measurements of bilirubin, proteins and inorganic substances (iron, copper, calcium and phosphate); it is recommended that these assays are not be performed within 24 hours of the examination.