Posology : מינונים

4.2 Posology and method of administration
Posology

The dose must always be adjusted to individual requirements of the patients, with the lowest possible starting dosage.

The following are guidelines:

Adults
Hypertension
Initially 25-50 mg once a day, the dosage being increased gradually to 100 mg a day after two weeks, as needed and tolerated.

Angina
Initially 50 mg once a day, the dosage being increased gradually to 100 mg after 1 week, as needed and tolerated.

Myocardial infarction
For patients who present some days after suffering an acute myocardial infarction, an oral dose of Normiten 100 mg daily is recommended for long-term prophylaxis of myocardial infarction 
Older population
Dosage requirements may be reduced, especially in patients with impaired renal function.

Paediatric population
There is no paediatric experience with Atenolol and for this reason Normiten is not recommended for use in children.

Renal failure
Since Atenolol is excreted via the kidneys, the dosage should be adjusted in cases of severe impairment of renal function.

No significant accumulation of Atenolol occurs in patients who have a creatinine clearance greater than 35 ml/min/1.73 m2 (normal range is 100–150 ml/min/1.73 m2).

For patients with a creatinine clearance of 15–35 ml/min/1.73 m2 (equivalent to serum creatinine of 300–600 micromol/litre), the oral dose should be 50 mg daily.

For patients with a creatinine clearance of less than 15 ml/min/1.73 m2 (equivalent to serum creatinine of greater than 600 micromol/litre), the oral dose should be 25 mg daily or 50 mg on alternate days.

Patients on haemodialysis should be given 50 mg orally after each dialysis; this should be done under hospital supervision as marked falls in blood pressure can occur.

Method of administration
For administration by the oral route.