Posology : מינונים

4.2    Posology and method of administration
Posology
Adults
Subcutaneous or Intramuscular Injection
The usual dose by subcutaneous or intramuscular injection is 5-20 mg every 4 hours.

Intravenous Injection
Doses of up to 15 mg have been given by slow intravenous injection, sometimes as a loading dose for continuous or patient-controlled infusion.

Elderly
Because of the depressant effect on respiration, caution is necessary when giving morphine to the elderly. A reduction of dose is advisable.

Hepatic Impairment
Morphine may precipitate coma in hepatic impairment – avoid or reduce dose.

Renal Impairment
A reduced maintenance dose may be necessary in moderate to severe impairment.

Discontinuation of therapy
An abstinence syndrome may be precipitated if opioid administration is suddenly discontinued. Therefore, the dose should be gradually reduced prior to discontinuation.

Method of administration
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Morphine Injection is intended for intramuscular, intravenous and subcutaneous administration.
The subcutaneous route is not suitable for oedematous patients.

Notes:
1. Resuscitative equipment and medications, including a specific antagonist (naloxone HCl injection) should be immediately available for management of respiratory depression or other complications that may arise from inadvertent morphine intravascular administration. Also, facilities for adequate monitoring of the patient’s respiratory status must be available for 24 hours after each dose since delayed respiratory depression may occur.

2. Rapid I.V. injection of most opioid analgesics has caused chest wall rigidity,
anaphylactoid reactions, severe respiratory depression, hypotension, peripheral circulatory collapse and cardiac arrest.
The patient usually should be lying down and should remain recumbent for a period of time to minimize side effects such as hypotension, dizziness, lightheadedness, nausea and vomiting. If these side effects occur in an ambulatory patient, they may be relieved if the patient lies down. An opioid antagonist and equipment for artificial ventilation should be available.