Posology : מינונים

4.2 Posology and method of administration
Posology
Unlike earlier tetracyclines, absorption of minocycline is not significantly impaired by food or moderate amounts of milk.

Adults:
Routine antibiotic use: 200mg daily in divided doses.

Acne: 50mg twice daily (or 100 mg once daily). Treatment should continue for a minimum of six weeks. If, after six months, there is no satisfactory response minocycline should be discontinued and other therapies considered. If minocycline is to be continued for longer than six months, patients should be monitored at least at three monthly intervals thereafter for signs and symptoms of hepatitis or SLE or unusual pigmentation of the skin. (See other special warnings and precautions).

Gonorrhoea: In adult males: 200mg initially followed by 100mg every 12 hours for a minimum of 4 days with post-therapy cultures within 2-3 days. Adult females may require more prolonged therapy.

Prophylaxis of asymptomatic meningococcal carriers: 100mg twice daily for five days, usually followed by a course of rifampicin.

Paediatric population:
Children over 12 years: 50mg every 12 hours (or 100 mg once daily).
Children under 12 years: Not recommended.

Elderly:
Dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Renal Impairment: minocycline may be used at the normal recommended dosage in mild to moderate renal impairment, however caution is advised in patients with severe renal impairment.

Method of Administration
For oral administration. To reduce the risk of oesophageal irritation and ulceration, the capsules should be swallowed whole with plenty of fluid, while sitting or standing.
Unlike earlier tetracyclines, absorption of minocycline is not significantly impaired by food or moderate amounts of milk.