Posology : מינונים

4.2 Posology and method of administration
Posology
Cadex may be administered in the morning or the evening.
Hypertension: Cadex is used in a once daily regimen: the initial dose is 1mg, to minimise the potential for postural hypotension and/or syncope (see section 4.4: Special warnings and precautions for use). Dosage may then be increased to 2mg after an additional one or two weeks of therapy and thereafter, if necessary to 4mg. The majority of patients who respond to Cadex will do so at a dose of 4mg or less. Dosage can be further increased if necessary to 8mg or the maximum recommended dose of 16mg.
Benign prostatic hyperplasia: The recommended initial dosage of Cadex is 1mg given once daily to minimise the potential for postural hypotension and/or syncope (see section 4.4).
Depending on the individual patient's urodynamics and BPH symptomatology dosage may then be increased to 2mg and thereafter to 4mg and up to the maximum recommended dose of 8mg.
The recommended titration interval is 1-2 weeks. The usual recommended dose is 2-4mg daily.
Paediatric population: The safety and efficacy of doxazosin in children and adolescents have not been established.
Elderly patients: Normal adult dosage.
Hepatic/Renal impairment
Patients with renal impairment: Since there is no change in pharmacokinetics in patients with impaired renal function, the usual adult dose of doxazosin is recommended.
Doxazosin is not dialysable.
Patients with hepatic impairment: There are only limited data in patients with liver impairment and on the effect of drugs known to influence hepatic metabolism (e.g. cimetidine). As with any drug wholly metabolised by the liver, doxazosin should be administered with caution to patients with evidence of impaired liver function (see section 4.4: Special warnings and precautions for use and section 5.2: Pharmacokinetic properties).
Method of administration
Oral administration