Posology : מינונים

4.2.   Posology and method of administration

Posology
Gelaspan 4% B.Braun is administered intravenously.
Dosage and infusion rate are adjusted according to the amount of blood loss and to individual needs for restoration and maintenance of a stable haemodynamic situation, respectively. The dose administered is initially 500 to 1000 ml on average, in case of severe blood loss higher doses have to be applied.
In adults and children weighing over 25 kg, 500 ml is administered at an appropriate rate depending on the haemodynamic status of the patient. In the case of more than 20 per cent blood loss usually blood or blood components should be given in addition to Gelaspan 4% B.Braun.

Pediatric population:
As documented experience regarding the use of Gelaspan 4% B.Braun in children is insufficient, the dosage must be adjusted very carefully according to the patient’s prevailing clinical condition and the therapy should be monitored especially carefully (see also section « Special warnings and Precautions for Us».)

Maximum Dose:
The maximum daily dose is determined by the degree of haemodilution. Care must be taken to avoid a decrease the haematocrit below critical values, see section «Special warnings and Precautions for Use».
If necessary, blood or packed red cells must be transfused additionally.
Attention must also be paid to the dilution of plasma proteins (e.g. albumin and coagulation factors), which must be adequately substituted if necessary.

Infusion rate:
The infusion rate depends on the actual haemodynamic situation.
Usually, 500 ml are infused over 30 min. However, the first 20 – 30 ml of solution should be infused slowly in order to detect the occurrence of an anaphylactoid reaction as early as possible. See also sections «Special warnings and Precautions for Use» and «Undesirable Effects».
In shock situations, Gelaspan 4% B.Braun may be infused rapidly by pressure infusion, 500 ml within 5 – 10 min.
The haemodynamic, haematological and coagulation system should be monitored.

Method of Administration
Intravenous use. When given rapidly Gelaspan 4% B.Braun should be warmed to not more than 37°C if possible.
When giving Gelaspan 4% B.Braun by pressure infusion, all air must be removed from containers with air space inside and from the infusion set before the solution is administered.