Posology : מינונים

4.2      Posology and method of administration

Dosage
The dosage is to be adjusted according to the individual glucose and fluid requirements.

Dosage for adults, the elderly and adolescents from 15 year of age

The maximum daily dose is 40 ml per kg body weight (BW), corresponding to 4 g of glucose per kg BW.


Note
In the presence of metabolic disorders (e.g. postoperatively or after injuries, hypoxia, organ insufficiencies), the oxidative metabolism of glucose may be impaired. In such situations the glucose intake should be limited to 2 – 4 g/kg BW/day. The blood glucose level should not exceed 6.1 mmol/l (110 mg/100 ml).

The maximum infusion rate is 2.5 ml per kg BW per hour, corresponding to 0.25 g of glucose per kg BW per hour. The maximum drop rate is 0.8 drops per kg BW per minute.

Thus for a patient weighing 70 kg the maximum infusion rate is approx. 175 ml/hour (corresponding maximum drop rate 58 drops/min), resulting in a glucose intake of 17.5 g/hour.

Dosage for Paediatric patients

The daily dose is limited by the maximum fluid intake:

1st day of life:          50-70 ml per kg BW
2nd day of life:          70-90 ml per kg BW
3rd day of life:          80 – 100 ml per kg BW
4th day of life:          100 – 120 ml per kg BW
From 5th day of life:     100 – 130 ml per kg BW
1st year:                 100 – 140 ml per kg BW
2st year:                 80 – 120 ml per kg BW
3rd –5th year:            80 – 100 ml per kg BW
6th –10th year:           60 - 80 ml per kg BW
11th –14th year:          50-70 ml per kg BW

The corresponding glucose amounts are below the maximum recommended glucose doses for the respective age groups.

If the solution is used as vehicle solution, a volume should be chosen that yields the desired concentration of the medicament to be dissolved or diluted.

Method of administration

Intravenous infusion. The solution can be administered peripherally.
If 10 % w/v Glucose Intravenous Infusion is used as vehicle solution the possibility of peripheral infusion depends on the characteristics of the mixture prepared.