Posology : מינונים

4.2   Posology and method of administration
Posology
The usual dosage is one intramuscular injection of Decapeptyl depot 22.5mg every 24 weeks under medical supervision.
Paediatric population
Precocious puberty (before 8 years in girls and 10 years in boys)
The treatment of children with Decapeptyl 22.5 mg should be under the overall supervision of a paediatric endocrinologist or of a paediatrician or an endocrinologist with expertise in the treatment of central precocious puberty.
Treatment should be stopped around the physiological age of puberty in boys and girls and should not be continued in girls with a bone maturation of more than 12-13 years. There are limited data available in boys relating to the optimum time to stop treatment based on bone age, however it is advised that treatment is stopped in boys with a bone maturation age of 13-14 years.
Treatment monitoring
Prostate cancer
The efficacy of treatment can be monitored by measuring serum levels of testosterone and prostate specific agent (PSA) and by subjective evaluation (symptomatic improvement e.g.
urinary symptoms, cancer pain etc)
Special dosage recommendations (refers to all dosages if not specified otherwise): Elderly patients: The dose does not have to be adapted to age.
The medicine is not indicated for post-menopausal women.
Hepatic or renal impairment: The dose does not have to be adjusted for patients suffering from limited hepatic or renal function.

Method of administration
As with other medicinal products administered by injection, the injection site should be varied periodically.
Once reconstituted, the suspension of Decapeptyl depot 22.5 mg should be intramuscularly injectedrelatively rapidly and uninterrupted manner in order to avoid any potential blockage of the needle.

Precautions to be taken before handling or administrating the medicinal product Decapeptyl depot 22.5 mg is only intended for intramuscular use.
Since Decapeptyl depot 22.5 mg is a suspension of microgranules, inadvertent intravascular injection must be strictly avoided.
Decapeptyl depot 22.5 mg must be administered under the supervision of a physician.
For instructions on reconstitution of the medicinal product before administration, see section 6.6.