Contraindications : התוויות נגד

        4.3 Contraindications

The medicine should not be used in the following cases:
The patient is pregnant or breast feeding,
Sensitivity (allergy) to the active ingredients or to any of the other ingredients contained in the medicine. For the full list of excipients, see section 6.1.
Children under the age of 12 years.
Children and adolescents above the age of 12 and under the age of 18 after a tonsillectomy or adenoidectomy for treatment obstructive sleep apnea, since these patients are more likely than others to suffer from breathing problems and there is an increased risk of developing serious and life-threatening adverse reactions.
In case the patient knows he produces a significant amount of morphine from a dose of codeine (belonging to the ultra-rapid metabolisers group), as he is at increased risk of suffering from severe side effects when using codeine.

Paracetamol & Codeine:
In patients for whom it is known they are CYP2D6 ultra-rapid metabolisers.

Atropine:
Atropine is contraindicated in patients with: prostatic enlargement, as it may lead to urinary retention.
paralytic ileus or pyloric stenosis.
angle-closure glaucoma or in patients with a narrow angle between the iris and the cornea as it may raise intra-ocular pressure and precipitate an acute attack.
myasthenia gravis (except to reduce muscarinic side effects of anticholinesterases).


Papaverine:
Papaverine is contraindicated in:
Complete atrioventricular heart block.
Administer with extreme caution when cardiac conduction is depressed, because of increased risk of transient ectopic rhythms of ventricular origin (premature beats or paroxysmal tachycardia).