Adverse reactions : תופעות לוואי

4.8 Undesirable effects
System Organ Class             Adverse reaction                   Frequency Immune system disorders        Hypersensitivity, angioedema,      Not known anaphylactic reaction.
Nervous system disorders       Cholinergic syndrome,              Not known especially at high doses. In patients with myasthenia gravis, cholinergic crisis may be difficult to distinguish from myasthenia crisis (see section
4.9).
Eye disorders                  Miosis, lacrimation increased      Not known Cardiac disorders              Bradycardia, decreased             Not known cardiac conduction, in severe cases possibly leading to heart block or cardiac arrest
Vascular disorders             Hypotension                        Not known Respiratory, thoracic or       Increased bronchial secretion,     Not known mediastinal disorders          bronchospasm
Gastrointestinal disorders     Nausea, vomiting, diarrhoea,       Not known abdominal cramps, salivary hypersecretion.


Increased intestinal motility may result in involuntary defecation.
Skin and subcutaneous tissue   Hyperhidrosis                      Not known disorders
Musculoskeletal, connective    Muscle spasms                      Not known tissue and bone disorders
Renal and urinary disorders    Urinary incontinence               Not known 

Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Any suspected adverse events should be reported to the Ministry of Health according to the National Regulation by using an online form: https://sideeffects.health.gov.il