Interactions : אינטראקציות

4.5   Interaction with other medicinal products and other forms of interaction
Medicinal products that influence the effect of testosterone
Barbiturates and other enzyme inducers
Interactions may occur with medicinal products that induce microsomal enzymes. This may also result in increased testosterone clearance.

The effect of androgens on other medicinal products

Oxyphenbutazone
There have been reports of increased serum oxyphenbutazone levels.
Oral anticoagulants
Testosterone and its derivatives have been reported to increase the effects of coumarin-derived oral anticoagulants. Close monitoring is therefore required in patients receiving oral anticoagulants , especially at the beginning or end of androgen therapy. Increased monitoring of the prothrombin time and more frequent INR determinations are recommended. Adjustment of the oral anticoagulant dose may be necessary. Independently of this observation, the limitations for intramuscular injection in patients with hereditary or acquired bleeding disorders must always be observed.


ACTH and corticosteroids
The concurrent administration of testosterone with ACTH or corticosteroids can promote oedema formation; therefore, these active substances should be administered cautiously, particularly in patients with cardiac or hepatic disease or in patients predisposed to oedema.


Antidiabetics
Androgens can increase insulin sensitivity and thereby reduce the doses of insulin or other antidiabetics needed for treatment (see section 4.4).


Effects on laboratory tests
Androgens may decrease levels of thyroxine-binding globulin, thereby resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4 in the uptake test. However, free thyroid hormone levels remain unchanged. There is no clinical evidence of impaired thyroid function.