Pregnancy & Lactation : הריון/הנקה

4.6 Fertility, pregnancy and lactation

Pregnancy
Dacarbazine has been shown to be mutagenic, teratogenic, and carcinogenic in animals. It must be assumed that an increased risk for teratogenic effects exists in humans. Therefore, Dacarbazine medac is contraindicated during pregnancy (see section 4.3.).

Women of childbearing potential / contraception in men and women
Due to the genotoxic potential of dacarbazine (see section 5.3), women of childbearing potential should use effective contraceptive measures while being treated with Dacarbazine medac and for 6 months following completion of treatment.
Men are recommended to use effective contraceptive measures and to not father a child while receiving Dacarbazine medac and for 3 months following completion of treatment.

Breastfeeding
Dacarbazine medac is contraindicated during breastfeeding (see section 4.3).

Fertility
Due to the genotoxic potential of dacarbazine, patients are advised to seek advice on fertility preservation options before starting treatment with dacarbazine. After treatment with dacarbazine, patients planning pregnancy are advised to seek genetic counselling.