Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
depending on tolerance, age and residual renal function.
The use of this peritoneal dialysis solution can lead to a loss of efficacy of other Automated peritoneal dialysis (APD)                                                                    medicinal products if these are dialysable through the peritoneal membrane. A dose If a machine (sleep•safe cycler or PD-NIGHT cycler) is used for intermittent or                        adjustment might be necessary.
continuous cyclic peritoneal dialysis, the use of larger bags is recommended providing                 A distinct reduction of the serum potassium level can increase the frequency of digitalis- more than one solution exchange. The cycler performs the solution exchanges                            associated adverse reactions. Potassium levels must be monitored particularly closely according to the medical prescription stored in the cycler.                                            during concurrent digitalis therapy (see section 4.4).
Adults:                                                                                                The use of diuretic agents may help maintain residual diuresis, but may also result in Typically patients spend 8-10 hours a night cycling. Dwell volumes range from 1500 to                  water and electrolyte imbalances.
3000 ml and the number of cycles usually varies from 3 to 10 per night. The amount                     In diabetic patients the daily dose of insulin or oral hypoglycaemic medicinal products of fluid used is typically between 10 and 18 l but can range from 6 to 30 l. The cycler                must be adjusted to take account of the increased glucose load.
therapy at night is usually combined with 1 or 2 exchanges during the daytime.
Paediatric population:                                                                                 balance 1.5%/2.3%/4.25% glucose, 1.75 mmol/l calcium The volume per exchange should be 800-1000 ml/m2 BSA with 5-10 exchanges                               The concomitant administration of calcium-containing medicinal products or overnight. It can be increased up to 1400 ml/m2 BSA depending on tolerance, age and                    vitamin D may cause hypercalcaemia.
residual renal function.